Gastrointestinal Endoscopy
Volume 56, Issue 2 , Pages 202-208 , August 2002

Nifedipine for prevention of post-ERCP pancreatitis: A prospective, double-blind randomized study

Presented as a poster at the annual Digestive Disease Week, May 20-23, 2001, Atlanta, Georgia (Gastrointest Endosc 2001;53:AB105), and as an oral communication at the 2001 edition of the “Journées Francophones de Pathologie Digestive,” March 24-28, 2001, Paris, France.

Received 16 July 2001 ,Revised 25 October 2001 ,Accepted 28 February 2002.

References 

  1. Baille J. Complications of endoscopy. Endoscopy. 1994;26:185–203
  2. Freeman ML, Nelson DB, Sherman S, Haber GB, Herman ME, Dorsher PJ, et al.  Complications of endoscopic biliary sphincterotomy. N Engl J Med. 1996;335:909–918
  3. Huibregtse K. Complications of endoscopic sphincterotomy and their prevention. N Engl J Med. 1996;335:961–963
  4. Skude G, Wehlin L, Maruyama T, Ariyama J. Hyperamylasemia after duodenoscopy and retrograde cholangiopancreatography. Gut. 1976;17:127–130
  5. Dickinson RJ, Davies S. Post-ERCP pancreatitis and hyperamylasemia: the role of operative and patient factors. Eur J Gastroenterol Hepatol. 1998;10:423–428
  6. Mehta SN, Pavone E, Barkun JS, Bouchard S, Barkun AN. Predictors of post-ERCP complications in patients with suspected choledocholithiasis. Endoscopy. 1998;30:457–463
  7. Sherman S, Rufolo TA. Hawes RH, Lehman GA. Complications of endoscopic sphincterotomy. A prospective series with emphasis on the increased risk associated with sphincter of Oddi dysfunction and nondilated bile ducts. Gastroenterology. 1991;101:1068–1754
  8. Binmoeller KF, Harris AG, Dumas R, Grimaldi C, Delmont JP. Does the somatostatin analogue octreotide protect against ERCP induced pancreatitis?. Gut. 1992;33:1129–1133
  9. Poon RTP, Yeung C, Lo CM, Yuen WK, Liu CL, Fan ST. Prophylactic effect of somatostatin on post-ERCP pancreatitis: a randomized controlled trial. Gastrointest Endosc. 1999;49:593–598
  10. Andriulli A, Leandro G, Niro G, Mangia A, Festa V, Gambassi G, et al.  Medical treatment can diminish pancreatic damages after ERCP: a metaanalysis. Gastrointest Endosc. 2000;51:1–7
  11. Sherman S, Lehman G, Earle D, Watkins J, Barnett J, et al.  Does prophylactic oral steroid administration reduce the frequency and severity of post-ERCP pancreatitis? Randomized prospective multicenter study [abstract]. Gastrointest Endosc. 1997;45:AB165
  12. De Palma GD, Catanzano C. Use of corticosteroids in the prevention of post-ERCP pancreatitis: results of a controlled prospective study. Am J Gastroenterol. 1999;94:982–985
  13. Cavallini G, Tittobello A, Frulloni C, Masci E, Mariani A, Di Francesco V. Gabexate in Digestive Endoscopy Italian group. Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. N Engl J Med. 1996;335:919–923
  14. Devière J, Le Moine O, Van Laethem JL, Eisendrath P, Ghilain A, Severs N, et al.  Interleukin 10 reduces the incidence of pancreatitis after therapeutic endoscopic retrograde cholangiopancreatography. Gastroenterology. 2001;120:498–505
  15. Leahy AL, Darzi A, Grace P, Qureshi A, Redmond P, Leader M, et al.  Verapamil is beneficial in a model of post-ERCP pancreatitis. Eur J Gastroenterol Hepatol. 1993;5:467–469
  16. Guelrud M, Mendoza S, Rossiter G, Ramirez L, Barkin J. Effect of nifedipine on sphincter of Oddi motor activity: studies in healthy volunteers and patients with biliary dyskinesia. Gastroenterology. 1988;95:1050–1055
  17. Sand J, Nordback I. Prospective randomized trial of the effect of nifedipine on pancreatic irritation after endoscopic retrograde cholangiopancreatography. Digestion. 1993;54:105–111
  18. Cotton PB, Lehman G, Vennes J, Geenen JE, Russell RC, Meyers WC, et al.  Endoscopic sphincterotomy complications and their management: an attempt at consensus. Gastrointest Endosc. 1991;37:383–393
  19. Ranson JH. The timing of biliary surgery in acute pancreatitis. Ann Surg. 1979;189:654–663
  20. Balthazar EJ, Ranson JH, Naidich DP, Megibow AS, Caccavale R, Cooper MM. Acute pancreatitis: prognostic value of CT. Radiology. 1985;158:767–772
  21. Geenen JE, Hogan WJ, Dodds WJ, Toouli S, Venu RP. The efficacy of endoscopic sphincterotomy after cholecystectomy in patients with sphincter-of-Oddi dysfunction. N Engl J Med. 1989;320:82–87
  22. Freeman ML, Nelson DE, Sherman S, Haber GB, Fennerty MB, Disario JA, et al.  Same day discharge after endoscopic biliary sphincterotomy: observations from a prospective multicenter complication study. Gastrointest Endosc. 1999;49:580–586

 Reprint requests: F. Prat, MD, Service des Maladies du Foie et de l'Apareil Digestif, CHU de Bicêtre, 78, rue de Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France.

PII: S0016-5107(02)70178-8

Gastrointestinal Endoscopy
Volume 56, Issue 2 , Pages 202-208 , August 2002