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BackgroundThe ingestion of caustic substances can represent a serious medical problem in children. ObjectiveWhether or not an urgent endoscopy should be performed is still a matter of debate, particularly in asymptomatic patients. DesignWe conducted a multicenter observational study to investigate the predictive value of signs and symptoms in detecting severe esophageal lesions. Setting and PatientsThe records of 162 children who presented with accidental caustic substance ingestion were analyzed. InterventionsSigns and symptoms were divided into minor (oral and/or oropharyngeal lesions and vomiting) and major (dyspnea, dysphagia, drooling, and hematemesis). An endoscopy was performed in all patients within 12 to 24 hours of the substance being ingested. Main Outcome MeasurementsThe types of substance ingested, signs and symptoms, age, sex, and severity of esophageal injury were correlated. ResultsMild esophageal lesions were identified in 143 of 162 patients (88.3%), and severe (third degree) esophageal lesions in 19 patients (11.7%). The risk of severe esophageal lesions without signs and/or symptoms was very low (odds ratio [OR] 0.13 [95% CI, 0.02-0.62], P = .002). Indeed, the presence of 3 or more symptoms is an important predictor of severe esophageal lesions (OR 11.97 [95% CI, 3.49-42.04], P = .0001). Multivariate analysis showed that the presence of symptoms is the most significant predictor of severe esophageal lesions (OR 2.3 [95% CI, 1.57-3.38], P = .001). ConclusionsThe results demonstrated that the incidence of patients with third-degree lesions without any early symptoms and/or signs is very low, and an endoscopy could be avoided. The risk of severe damage increases proportionally with the number of signs and symptoms, and an endoscopy is always mandatory in symptomatic patients. Padua, Rome, Naples, Brescia, Casarano, Viterbo, Parma, Florence, Turin, Treviso, Italy Abbreviation: OR, odds ratio Current affiliations: Pediatric Surgery Clinic (P.B., S.G., P.G.), University of Padova, Padova, Department of Pediatric Surgery (D.F.), Ospedali Civili, Brescia, Digestive Surgery and Endoscopy Unit (A.P., L.D.O.), Ospedale Pediatrico Bambino Gesù, Roma, Pediatric Gastroenterology and Endoscopic Unit (G.L.A.), University of Parma, Pediatric Department (M.C.), Hospital Santobono, Napoli, Policlinico Universitario (C.R.), University of Messina, Messina, Department of Environmental Medicine and Public Health (V.B.), Institute of Hygiene, University of Padova, Padova, Italy
Caustic Ingestion Italian Study Group: Greta Bordignon, MD, Department of Environmental Medicine and Public Health, Institute of Hygiene, University of Padova, Padova; Giovanni Boroni, MD, Department of Pediatric Surgery, Ospedali Civili, Brescia; Alessandro Crocoli, MD, Digestive Surgery and Endoscopy Unit, Ospedale Pediatrico Bambino Gesù, Roma; Marco Gasparella, MD, Pediatric Surgery Unit, Treviso; Luigi Liotta, MD, Pediatric Surgery Unit, Casarano; Manola Lisiero, MD, Department of Environmental Medicine and Public Health, Institute of Hygiene, University of Padova, Padova; Roberto Lo Piccolo, MD, Department of Pediatric Surgery and Burn Unit, Anna Meyer Childern's Hospital, Florence; Tamara Sabbi, Md, Pediatric Unit, BelColle Hospital, Viterbo; Nicola Tommasoni, MD, Pediatric Surgery Unit, Children Hospital OIRM, Torino, Italy. See CME section; p. 531. PII: S0016-5107(08)00216-2 doi:10.1016/j.gie.2008.02.016 © 2008 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.
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ABSTRACT
Caustic ingestion in children: is endoscopy always indicated? The results of an Italian multicenter observational study
CME Activity: Continuing Medical Examination Exam: September 2008
