Gastrointestinal Endoscopy
Volume 68, Issue 3 , Pages 548-553 , September 2008

Creation of an effective and reproducible nonsurvival porcine model that simulates actively bleeding peptic ulcers

Received 21 August 2006 ,Accepted 17 March 2008.

References 

  1. Kozak LJ, Owings MF, Hall MJ. National Hospital Discharge Survey: 2002 annual summary with detailed diagnosis and procedure data. Vital Health Stat. 2005;13:1–199
  2. Kozak LJ, Owings MF, Hall MJ. National Hospital Discharge Survey: 2001 annual summary with detailed diagnosis and procedure data. Vital Health Stat. 2004;13:1–198
  3. Vreeburg EM, Snel P, de Bruijne JW, et al. Acute upper gastrointestinal bleeding in the Amsterdam area: incidence, diagnosis, and clinical outcome. Am J Gastroenterol. 1997;92:236–243
  4. Rockall TA, Logan RF, Devlin HB, et al. Risk assessment after acute upper gastrointestinal haemorrhage. Gut. 1996;38:316–321
  5. Czernichow P, Hochain P, Nousbaum JB, et al. Epidemiology and course of acute upper gastro-intestinal haemorrhage in four French geographical areas. Eur J Gastroenterol Hepatol. 2000;12:175–181
  6. Laine L, Peterson WL. Bleeding peptic ulcer. N Engl J Med. 1994;331:717–727
  7. Rockall TA, Logan RF, Devlin HB, et al. Incidence of and mortality from acute upper gastrointestinal haemorrhage in the United Kingdom. Steering Committee and members of the National Audit of Acute Upper Gastrointestinal Haemorrhage. BMJ. 1995;311:222–226
  8. Protell RL, Silverstein FE, Piercey J, et al. A reproducible animal model of acute bleeding ulcer—the “ulcer maker. Gastroenterology. 1976;71:961–964
  9. Johnston JH, Jensen DM, Auth D. Experimental comparison of endoscopic yttrium-aluminum-garnet laser, electrosurgery, and heater probe for canine gut arterial coagulation. Importance of compression and avoidance of erosion. Gastroenterology. 1987;92:1101–1108
  10. Dennis MB, Silverstein FE, Gilbert DA, et al. Evaluation of Nd:YAG photocoagulation using a new experimental ulcer model with a single bleeding artery. Gastroenterology. 1981;80:1522–1527
  11. Randall GM, Jensen DM, Hirabayashi K, et al. Controlled study of different sclerosing agents for coagulation of canine gut arteries. Gastroenterology. 1989;96:1274–1281
  12. Deng XY, Zheng ZT. [An animal model of peptic ulcer induced by destruction of dopaminergic neurons]. Zhonghua Nei Ke Za Zhi. 1994;33:313–316
  13. Pinkas H, McAllister E, Norman J, et al. Prolonged evaluation of epinephrine and normal saline solution injections in an acute ulcer model with a single bleeding artery. Gastrointest Endosc. 1995;42:51–55
  14. Mall AS, Hickman R, Terblanche J, et al. The pig as an ulcer model. Gastroenterology. 1997;113:366–367
  15. Terblanche J, van Hoorn-Hickman R. The prevention of peptic ulceration by highly selective vagotomy in a new peptic ulcer experimental model: the bile duct-ligated pig. Surgery. 1978;84:206–211
  16. Hu B, Chung SC, Sun LC, et al. Developing an animal model of massive ulcer bleeding for assessing endoscopic hemostatic devices. Endoscopy. 2005;37:847–851
  17. Chiu PW, Hu B, Lau JY, et al. Endoscopic application of massively bleeding peptic ulcer by using the Eagle Claw VII device: a feasibility study in a porcine model. Gastrointest Endosc. 2006;63:681–685
  18. Wong RC. Endoscopic Doppler US probe for acute peptic ulcer hemorrhage. Gastrointest Endosc. 2004;60:804–812
  19. Hochberger J, Matthes K, Maiss J, et al. Training with the compactEASIE biologic endoscopy simulator significantly improves hemostatic technical skill of gastroenterology fellows: a randomized controlled comparison with clinical endoscopy training alone. Gastrointest Endosc. 2005;61:204–215
  20. Maiss J, Wiesnet J, Proeschel A, et al. Objective benefit of a 1-day training course in endoscopic hemostasis using the “compactEASIE” endoscopy simulator. Endoscopy. 2005;37:552–558
  21. Maiss J, Baumback C, Zopf Y, et al. Hemodynamic efficacy of the new resolution clip device in comparison with high-volume injection therapy in spurting bleeding: a prospective experimental trial using the compactEASIE simulater. Endoscopy. 2006;38:808–812
  22. Maiss J, Dumser C, Zopf Y, et al. “Hemodynamic efficacy” of two endoscopic clip devices used in the treatment of bleeding vessels, tested in an experimental setting using the compact Erlangen Active Simulator for Interventional Endoscopy (compactEASIE) training model. Endoscopy. 2006;38:575–580
  23. Bhutani MS, Wong RF, Hoffman BJ. Training facilities in gastrointestinal endoscopy: an animal model as an aid to learning endoscopic ultrasound. Endoscopy. 2006;38:932–934

 Presented at Digestive Disease Week 2006, May 20-24, 2006, Los Angeles, California (Gastrointest Endosc 2006;63:AB238).

PII: S0016-5107(08)01568-X

doi: 10.1016/j.gie.2008.03.1087

Gastrointestinal Endoscopy
Volume 68, Issue 3 , Pages 548-553 , September 2008

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