Gastrointestinal Endoscopy
Volume 69, Issue 1 , Pages 3-9 , January 2009

Intravenous proton pump inhibition utilization and prescribing patterns escalation: a comparison between early and current trends in use

Received 21 September 2006 ,Accepted 19 April 2008.

References 

  1. Trepanier EF. Intravenous pantoprazole: a new tool for acutely ill patients who require acid suppression. [review] Can J Gastroenterol. 2000;14(D Suppl):11–20D
  2. Barkun A, Sabbah S, Enns R, et al. The Canadian Registry on Nonvariceal Upper Gastrointestinal Bleeding and Endoscopy (RUGBE): endoscopic hemostasis and proton pump inhibition are associated with improved outcomes in a real-life setting. Am J Gastroenterol. 2004;99:1238–1246
  3. Barkun AN, Cockeram AW, Plourde V, et al. Review article: acid suppression in non-variceal acute upper gastrointestinal bleeding. [review] Aliment Pharmacol Ther. 1999;13:1565–1584
  4. Daneshmend TK, Hawkey CJ, Langman MJ, et al. Omeprazole versus placebo for acute upper gastrointestinal bleeding: randomised double blind controlled trial. [comment] BMJ. 1992;304:143–147
  5. Gisbert JP, Gonzalez L, Calvet X, et al. Proton pump inhibitors versus H2-antagonists: a meta-analysis of their efficacy in treating bleeding peptic ulcer. Aliment Pharmacol Ther. 2001;15:917-6
  6. Hasselgren G, Lind T, Lundell L, et al. Continuous intravenous infusion of omeprazole in elderly patients with peptic ulcer bleeding: results of a placebo-controlled multicenter study. Scand J Gastroenterol. 1997;32:328–333
  7. Javid G, Masoodi I, Zargar SA, et al. Omeprazole as adjuvant therapy to endoscopic combination injection sclerotherapy for treating bleeding peptic ulcer. Am J Med. 2001;111:280–284
  8. Lau JY, Chung S. Management of upper gastrointestinal haemorrhage. [review] J Gastroenterol Hepatol. 2000;15(Suppl):G8–G12
  9. Lin HJ, Lo WC, Lee FY, et al. A prospective randomized comparative trial showing that omeprazole prevents rebleeding in patients with bleeding peptic ulcer after successful endoscopic therapy. Arch Intern Med. 1998;158:54–58
  10. Schaffalitzky de Muckadell OB, Havelund T, Harling H, et al. Effect of omeprazole on the outcome of endoscopically treated bleeding peptic ulcers: randomized double-blind placebo-controlled multicentre study. Scand J Gastroenterol. 1997;32:320–327
  11. Spiegel B, Ofman J, Woods K, et al. Minimizing recurrent peptic ulcer hemorrhage after endoscopic hemostasis: the cost effectiveness of competing strategies. Am J Gastroenterol. 2003;98:86–97
  12. Villanueva C, Balanzo J, Torras X, et al. Omeprazole versus ranitidine as adjunct therapy to endoscopic injection in actively bleeding ulcers: a prospective and randomized study. Endoscopy. 1995;27:308–312
  13. Yacyshyn BR, Thomson AB. Critical review of acid suppression in nonvariceal, acute, uppergastrointestinal bleeding. [review] Dig Dis. 2000;18:117–128
  14. Zed PJ, Loewen PS, Slavik RS, et al. Meta-analysis of proton pump inhibitors in treatment of bleeding peptic ulcers. Ann Pharmacother. 2001;35:1528–1534
  15. Barkun A, Bardou M, Marshall JK, et al. Consensus recommendations for managing patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2003;139:843–857
  16. Lau JY, Sung JJ, Lee KK, et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med. 2000;343:310–316
  17. Lau JY, Leung WK, Wu JC. Omeprazole before endoscopy in patients with gastrointestinal bleeding. N Engl J Med. 2007;356:1631–1640
  18. Green FW, Kaplan MM, Curtis LE, et al. Effect of acid and pepsin on blood coagulation and platelet aggregation: a possible contributor prolonged gastroduodenal mucosal hemorrhage. Gastroenterology. 1978;74:38–43
  19. Hasselgren G, Keelan M, Kirdeikis P, et al. Optimization of acid suppression for patients with peptic ulcer bleeding: an intragastric pH-metry study with omeprazole. Eur J Gastroenterol Hepatol. 1998;10:601–606
  20. Patchett SE, Enright H, Afdhal N, et al. Clot lysis by gastric juice: an in vitro study. Gut. 1989;30:1704–1707
  21. Patchett SE, O'Donoghue DP. Pharmacological manipulation of gastric juice: thrombelastographic assessment and implications for treatment of gastrointestinal haemorrhage. Gut. 1995;36:358–362
  22. Tseng GY, Lin HJ, Lin HY, et al. The influence of intravenous omeprazole on intragastric pH and outcomes in patients with peptic ulcer bleeding after successful endoscopic therapy—a prospective randomized comparative trial. Hepatogastroenterology. 1999;46:2183–2188
  23. Walt RP, Reynolds JR, Langman MJ, et al. Intravenous omeprazole rapidly raises intragastric pH. Gut. 1985;26:902–906
  24. Berstad A. Does profound acid inhibition improve haemostasis in peptic ulcer bleeding?. Scand J Gastroenterol. 1997;32:396–398
  25. Panto IV. Wyeth Pharmaceuticals. May 2008. Available at: www.wyeth.com. Accessed June 10, 2008.
  26. Protonix. Wyeth Pharmaceuticals. December 2007. Available at: www.wyeth.com. Accessed June 10, 2008.
  27. Lau JY, Sung JJ, Lee KK, et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med. 2000;343:310–316
  28. Charlson ME, Pompei P, Ales KI, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis. 1987;40:373–383
  29. Enns R, Andrews CN, Fishman M, et al. Description of prescribing practices in patients with upper gastrointestinal bleeding receiving intravenous proton pump inhibitors: a multicentre evaluation. Can J Gastroenterol. 2004;18:567–571
  30. Andrews CN, Levy A, Fishman M, et al. Intravenous proton pump inhibitors before endoscopy in bleeding peptic ulcer with high risk stigmata: a multicentre comparative study. Can J Gastroenterol. 2005;19:667–671
  31. Enns RA, Gagnon YM, Rioux KP, et al. Cost-effectiveness in Canada of intravenous proton pump inhibitors for all patients presenting with acute upper gastrointestinal bleeding. Aliment Pharmacol Ther. 2003;17:225–233
  32. Gagnon YM, Levy AR, Eloubeidi MA, et al. Cost implications of administering intravenous proton pump inhibitors to all patients presenting to the emergency department with peptic ulcer bleeding. Value Health. 2003;6:457–465

 If you want to chat with an author of this article, you may contact him at renns@interchange.ubc.ca.

 DISCLOSURE: The authors report that there are no disclosures relevant to this publication.

PII: S0016-5107(08)01808-7

doi: 10.1016/j.gie.2008.04.053

Gastrointestinal Endoscopy
Volume 69, Issue 1 , Pages 3-9 , January 2009

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