Gastrointestinal Endoscopy
Volume 69, Issue 6 , Pages e31-e37 , May 2009

Does glyceryl nitrate prevent post-ERCP pancreatitis? A prospective, randomized, double-blind, placebo-controlled multicenter trial

Received 26 May 2008 ,Accepted 20 November 2008.

References 

  1. Freeman ML. Post-ERCP pancreatitis: patient and technique-related risk factors. JOP. 2002;3:169–176
  2. Andriulli A, Clemente R, Solmi L, et al. Gabexate or somatostatin administration before ERCP in patients at high risk for post-ERCP pancreatitis: a multicenter, placebo-controlled, randomized clinical trial. Gastrointest Endosc. 2002;56:488–495
  3. Andriulli A, Solmi L, Loperfido S, et al. Prophylaxis of ERCP-related pancreatitis: a randomized, controlled trial of somatostatin and gabexate mesylate. Clin Gastroenterol Hepatol. 2004;2:713–718
  4. Li ZS, Pan X, Zhan WJ, et al. Effect of octreotide administration in the prophylaxis of post-ERCP pancreatitis and hyperamylasemia: a multicenter, placebo-controlled, randomized clinical trial. Am J Gastroenterol. 2007;102:46–51
  5. Manes G, Ardizzone S, Lombardi G, et al. Efficacy of postprocedure administration of gabexate mesylate in the prevention of post-ERCP pancreatitis: a randomized controlled multicenter study. Gastrointest Endosc. 2007;65:982–987
  6. Murray B, Carter R, Imrie C, et al. Diclofenac reduces the incidence of acute pancreatitis after endoscopic retrograde cholangiopancreatography. Gastroenterology. 2003;124:1786–1791
  7. Sotoudehmanesh R, Khatibian M, Kolahdoozan S, et al. Indomethacin may reduce the incidence and severity of acute pancreatitis after ERCP. Am J Gastroenterol. 2007;102:978–983
  8. Dumot JA, Conwell DL, Zuccaro G, et al. A randomized, double blind study of interleukin 10 for the prevention of ERCP-induced pancreatitis. Am J Gastroenterol. 2001;96:2098–2102
  9. Devière J, Le Moine O, Van Laethem JL, et al. Interleukin 10 reduces the incidence of pancreatitis after therapeutic endoscopic retrograde cholangiopancreatography. Gastroenterology. 2001;120:498–505
  10. Sand J, Nordback I. Prospective randomized trial of the effect of nifedipine on pancreatic irritation after therapeutic endoscopic retrograde cholangiopancreatography. Digestion. 1993;54:105–111
  11. Moretó M, Zaballa M, Casado I, et al. Transdermal glyceryl nitrate for prevention of post-ERCP pancreatitis: a randomized double-blind trial. Gastrointest Endosc. 2003;57:1–7
  12. Sudhindran S, Bromwich E, Edwards PR. Prospective randomized double-blind placebo-controlled trial of glyceryl nitrate in therapeutic endoscopic retrograde cholangiopancreatography-induced pancreatitis. Br J Surg. 2001;88:1178–1182
  13. Harrison LI, Riedel JL, Machacek JH, et al. Bioequivalence comparison of two drug-in-adhesive transdermal nitroglycerin patches. Am J Ther. 1996;3:580–585
  14. Bradley EL. A clinically based classification system for acute pancreatitis: summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. Arch Surg. 1993;128:586–590
  15. Cotton PB, Lehman G, Vennes J, et al. Endoscopic sphincterotomy complications and their management: an attempt at consensus. Gastrointest Endosc. 1991;37:383–393
  16. Testoni PA. Preventing post-ERCP pancreatitis: where are we?. JOP. 2003;4:22–32
  17. Pande H, Thuluvath PJ. Pharmacological prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis. Drugs. 2003;63:1799–1812
  18. Freeman MI. Prevention of post-ERCP pancreatitis: pharmacologic solution or patient selection and pancreatic stents?. Gastroenterology. 2003;124:1977–1980
  19. Williams EJ, Taylor S, Fairclough P, et al. Risk factors for complication following ERCP: results of a large-scale, prospective multicenter study. Endoscopy. 2007;39:793–801
  20. Demols A, Deviere J. New frontiers in the pharmacological prevention of post-ERCP pancreatitis: the cytokines. JOP. 2003;4:49–57
  21. Mariani A. Pharmacological prevention of post-ERCP pancreatitis: which therapy is best?. JOP. 2003;4:68–74
  22. Kaffes AJ, Bourke MJ, Ding S, et al. A prospective, randomized, placebo-controlled trial of transdermal glyceryl trinitrate in ERCP: effects on technical success and post-ERCP pancreatitis. Gastrointest Endosc. 2006;64:351–357
  23. Barrioz T, Beauchant M French Multicenter Group. Intravenous nitroglycerine for the prevention of pancreatitis after therapeutic endoscopic retrograde cholangiopancreatography: a randomised, double blind, placebo controlled multicenter trial. Endoscopy. 2006;55(V Suppl):A24;OP-G-101

 DISCLOSURE: All authors disclosed no financial relationships relevant to this publication.

 The EPEPPS-group, contributors: Ulrich Bang, Department of Gastroenterology, Hvidovre Hospital, Hvidovre, Denmark; Finn Møller Pedersen and Ove B Schaffalitzky de Muckadell, Department of Internal Medicine S, Odense University Hospital, Odense, Denmark; Taran Søberg, Division of Gastroenterology, Østfold County Hospital Fredrikstad, Fredrikstad, Norway; Lars Karlsen and Tom Glomsaker, Department of Internal Medicine and Surgery, Stavanger University Hospital, Stavanger, Norway; Peter Vilman, Department of Surgery D, Gentofte Hospital, Gentofte, Denmark; Trine Stigaard Larsen, Mikkel Westen, Svend Schulze, Department of Internal Medicine M and Surgery D, Glostrup Hospital, Glostrup, Denmark; Hans Kromann Andersen and Peter Vestergaard, Department of Gastroenterology and Surgery, Roskilde County Hospital Køge, Denmark; Mette Skov, Mark James McCullagh, Lars Bo Svendsen, Department of Gastroenterological Surgery CTX, Rigshospitalet, Copenhagen, Denmark; Nathalie Lesavre, Center of Clinical Investigation, North Hospital, Marseille, France; Marc Barthet, Department of Gastroenterology, North Hospital, Marseille, France; Per Almquist, Ervin Toth, Department of Surgery, Malmö University Hospital, Malmö, Sweden; Bengt Börjesson and Hans Högström, Department of Surgery, Halmstad Hospital, Halmstad, Sweden; José Sahel, Department of Gastroenterology, Conception Hospital, Marseille, France; Martin Theil Jensen, Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark.

 If you want to chat with an author of this article, you may contact her at mille@dadlnet.dk.

PII: S0016-5107(08)03010-1

doi: 10.1016/j.gie.2008.11.042

Gastrointestinal Endoscopy
Volume 69, Issue 6 , Pages e31-e37 , May 2009

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