Gastrointestinal Endoscopy
Volume 72, Issue 1 , Pages 112-117 , July 2010

A prospective, randomized, comparative trial evaluating respiratory depression during patient-controlled versus anesthesiologist-administered propofol-remifentanil sedation for elective colonoscopy

Presented at Simultaneous Plenary Session of ACG, 2008, Orlando, Florida.

Received 13 June 2009 ,Accepted 5 January 2010.

References 

  1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71–96
  2. Cohen LB, Wecsler JS, Gaetano JN, et al. Endoscopic sedation in the United States: results from a nationwide survey. Am J Gastroenterol. 2006;101:967–974
  3. Inadomi JM, Gunnarsson CL, Rizzo JA, et al. Projected growth rate of anesthesiologist-delivered sedation in colonoscopy and EGD in the United States: 2009-2011. Gastrointest Endosc. 2009;AB111:
  4. Rex DK. Review article: moderate sedation for endoscopy: sedation regimens for non-anaesthesiologists. Aliment Pharmacol Ther. 2006;24:163–171
  5. Aisenberg J, Cohen LB, Piorkowski JD. Propofol use under the direction of trained gastroenterologists: an analysis of the medicolegal implications. Am J Gastroenterol. 2007;102:707–713
  6. Mandel JE, Tanner JW, Lichtenstein GR, et al. A randomized, controlled, double-blind trial of patient-controlled sedation with propofol/remifentanil versus midazolam/fentanyl for colonoscopy. Anesth Analg. 2008;106:434–439
  7. Budnyk SA. Judgment and risk to patient in study design. Anesth Analg. 2008;107:724–725author reply 725-6
  8. Bruhn J, Myles PS, Sneyd R, et al. Depth of anaesthesia monitoring: what's available, what's validated and what's next?. Br J Anaesth. 2006;97:85–94
  9. Stonell CA, Leslie K, Absalom AR. Effect-site targeted patient-controlled sedation with propofol: comparison with anaesthetist administration for colonoscopy. Anaesthesia. 2006;61:240–247
  10. Schnider TW, Minto CF, Gambus PL, et al. The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. Anesthesiology. 1998;88:1170–1182
  11. Minto CF, Schnider TW, Egan TD, et al. Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil (I. Model development). Anesthesiology. 1997;86:10–23
  12. Bouillon TW, Bruhn J, Radulescu L, et al. Pharmacodynamic interaction between propofol and remifentanil regarding hypnosis, tolerance of laryngoscopy, bispectral index, and electroencephalographic approximate entropy. Anesthesiology. 2004;100:1353–1372
  13. Mandel JE. Clinical evaluation of a method for producing probability ramp sedation with propofol and remifentanil during colonoscopy. Paper presented at: Annual meeting of the Society for Technology in Anesthesia; January 13-14, 2009; San Antonio, TX. Available at: http://www.anestech.org/media/Publications/Annual_2009/2009_STA_Abstracts.pdf
  14. Brainard DH. The Psychophysics Toolbox. Spat Vis. 1997;10:433–436
  15. Atkins JH, Mandel JE. Recent advances in patient-controlled sedation. Curr Opin Anaesthesiol. 2008;21:759–765
  16. Drews FA, Syroid N, Agutter J, et al. Drug delivery as control task: improving performance in a common anesthetic task. Hum Factors. 2006;48:85–94
  17. Macario A, Scibetta WC, Navarro J, et al. Analgesia for labor pain: a cost model. Anesthesiology. 2000;92:841–850

 DISCLOSURE: The following authors disclosed financial relationships relevant to this publication: J.E. Mandel: Speaker for Bioniche Pharma. G.R. Lichtenstein: Advisory committee and lecture funding: Consultant: Abbott Laboratories. M.L. Kochman: Spouse: stock and executive: Merck.

PII: S0016-5107(10)00045-3

doi: 10.1016/j.gie.2010.01.031

Gastrointestinal Endoscopy
Volume 72, Issue 1 , Pages 112-117 , July 2010

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