Gastrointestinal Endoscopy
Volume 72, Issue 3 , Pages 497-504, September 2010

Short-term safety and efficacy of the Trans-oral Endoscopic Restrictive Implant System for the treatment of obesity

Current affiliations: Department of Gastroenterology and Hepatology (K.d J., E.M.H.M.-V., P.F.), Department of Nutrition and Dietetics (E.A.M.L.V.), Department of Anesthesiology (J.H.E.), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Received 18 November 2009; accepted 19 February 2010. published online 11 June 2010.

Background

Medical treatment of obesity often fails, and surgical treatment, although successful, is aggressive.

Objective

To evaluate the short-term safety and efficacy of an endoscopic restrictive implant procedure in the treatment of obesity.

Design

Prospective, observational study.

Setting

Tertiary-care referral hospital in The Netherlands.

Patients

This study involved 13 patients with body mass indexes of between 40 and 50 kg/m2 or between 35 and 40 kg/m2 with obesity-related comorbidities.

Intervention

A new transoral endoscopic restrictive implant procedure in the treatment of obesity.

Main Outcome Measurements

Safety of the procedure, percentage of excess weight loss, change in body mass index.

Results

In 1 patient, the procedure was abandoned after a gastric perforation related to stapler malfunctioning. In 2 patients, pneumoperitoneum was detected. This was desufflated with a percutaneous hollow needle in one patient and treated conservatively in the other. After these complications, technical adjustments were made in the procedure, and no subsequent procedural complications were seen. At 3 months postprocedure, patients obtained a median excess weight loss of 28%. Median body mass index decreased from 42.1 to 37.9 kg/m2.

Limitations

Small number of patients.

Conclusion

Preliminary results of this transoral endoscopic restrictive implant system for the treatment of obesity showed successful placement in 12 of 13 patients. Procedural complications occurred in 3 patients. Weight loss was comparable to that of laparoscopic gastric band placement. Further long-term studies are under way.

Abbreviations: BMI, body mass index, TERIS, Trans-oral Endoscopic Restrictive Implant System

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 DISCLOSURE: All authors disclosed no financial relationships relevant to this publication.

 If you would like to chat with an author of this article, you may contact Dr Fockens at p.fockens@amc.nl.

PII: S0016-5107(10)00265-8

doi:10.1016/j.gie.2010.02.053

Gastrointestinal Endoscopy
Volume 72, Issue 3 , Pages 497-504, September 2010

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