Usefulness of magnifying endoscopy with narrow-band imaging for determining the horizontal extent of early gastric cancer when there is an unclear margin by chromoendoscopy (with video)

Background

Magnifying endoscopy (ME) with narrow-band imaging (NBI) may allow reliable delineation of the horizontal extent of early gastric cancers before endoscopic submucosal dissection (ESD). However, the advantages of ME with NBI over standard endoscopy with dye spraying (chromoendoscopy [CE]) have yet to be elucidated.

Objective

To investigate the usefulness and limitations of ME with NBI when CE is unsuccessful for determining the horizontal extent of early gastric cancer.

Design

Case series.

Setting

Single tertiary referral center.

Materials

Series of 350 consecutive early gastric cancers resected en bloc using ESD.

Intervention

ME with NBI for cancers with unclear margins by CE.

Main Outcome Measurements

The rate of successful delineation by ME with NBI for cancers that had demonstrated unclear margins using CE.

Results

The proportion of cancers showing unclear margins using CE was 18.9% (66/350). Of these, 62 of 66 cancers were examined using ME with NBI, with the entire margins successfully delineated in 72.6% (45/62) of the lesions that had shown unclear margins using CE. The success rate was 0% for undifferentiated cancers, significantly lower than that for differentiated lesions (P < .00001).

Limitations

Even by using ME with NBI, endoscopic delineation remains difficult for undifferentiated lesions.

Conclusions

ME with NBI is an excellent modality for identifying the entire margin of early gastric cancers, when the margins are unclear using CE.

Abbreviations:  CE, chromoendoscopy, ESD, endoscopic submucosal dissection, ME, magnifying endoscopy, NBI, narrow-band imaging, MS, microsurface, MV, microvascular