An endoscopic wireless gastrostimulator (with video)

Deb, Sanchali; Tang, Shou-Jiang; Abell, Thomas L.; Rao, Smitha; Huang, Wen-Ding; To, S.D. Filip; Lahr, Christopher; Chiao, Jung-Chih

doi:10.1016/j.gie.2011.09.052

« Previous Next »Gastrointestinal Endoscopy
Volume 75, Issue 2 , Pages 411-415.e1, February 2012

An endoscopic wireless gastrostimulator (with video)

Sanchali Deb, PhD
- Department of Electrical Engineering, University of Texas at Arlington, Arlington, TX
Shou-Jiang Tang, MD
- Division of Digestive Diseases, Department of Medicine, University of Mississippi Medical Center, Jackson, MS
Thomas L. Abell, MD
- Division of Digestive Diseases, Department of Medicine, University of Mississippi Medical Center, Jackson, MS
- Reprint requests: Thomas L. Abell, MD, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216
Smitha Rao, PhD
- Department of Electrical Engineering, University of Texas at Arlington, Arlington, TX
Wen-Ding Huang, PhD
- Department of Electrical Engineering, University of Texas at Arlington, Arlington, TX
S.D. Filip To, PhD
- Agricultural and Biological Engineering Department, Bagley College of Engineering, Mississippi State University, Starkville, Mississippi, USA
Christopher Lahr, MD
- Department of Surgery, University of Mississippi Medical Center, Jackson, MS
Jung-Chih Chiao, PhD
- Department of Electrical Engineering, University of Texas at Arlington, Arlington, TX

Received 1 July 2011; accepted 30 September 2011.

Background

Gastric electric stimulation (GES) at a high-frequency, low-energy setting is an option for treating refractory gastroparesis. The currently available commercial stimulator, the Enterra neurostimulator (Medtronic Inc, Minneapolis, MN), however, requires surgical implantation and is powered by a nonrechargeable battery.

Objective

To develop and test a miniature wireless GES device for endoscopic implantation in an experimental model.

Design

In-vivo gastric signals were recorded and measured in a nonsurvival swine model (n = 2; 110-lb animals).

Intervention

An endoscopically placed, wireless GES device was inserted into the stomach through an overtube; the two GES electrodes were endoscopically attached to the gastric mucosa and secured with endoclips to permit stimulation.

Main Outcome Measurements

Stable electrogastrogram measures were observed during GES stimulation.

Results

Electrogastrogram recordings demonstrated that gastric slow waves became more regular and of constant amplitudes when stomach tissues were stimulated, in comparison with no stimulation. The frequency-to-amplitude ratio also changed significantly with stimulation.