Background
We previously reported on the efficacy of endocytoscopic classification (EC-C). However,
the correlation of the endocytoscopic vascular (EC-V) pattern with diagnoses was unclear.
Objective
To assess the diagnostic accuracy of the EC-V pattern for colorectal lesions.
Design
Retrospective.
Setting
A university hospital.
Patients
Patients who underwent endocytoscopy between January 2010 and March 2013.
Intervention
We evaluated 198 consecutive lesions according to the EC-V pattern (EC-V1, obscure
surface microvessels; EC-V2, clearly observed surface microvessels of a uniform caliber
and arrangement; and EC-V3, dilated surface microvessels of a nonhomogeneous caliber
or arrangement).
Main Outcome Measurements
The diagnostic accuracy for predicting hyperplastic polyps and invasive cancer were
compared between the EC-V pattern and other modalities (narrow-band imaging, pit pattern,
and EC-C).
Results
The sensitivity, specificity, and accuracy of the EC-V1 pattern for diagnosing hyperplastic
polyps were 95.5%, 99.4%, and 99.0%, respectively. The sensitivity, specificity, and
accuracy of the EC-V3 pattern for diagnosing invasive cancer were 74.6%, 97.2%, and
88.6%, respectively. The diagnostic accuracy of the EC-V pattern for predicting hyperplastic
polyps was comparable to the other modalities. For predicting invasive cancer, the
EC-V pattern was comparable to narrow-band imaging and pit pattern, although EC-C
was slightly more accurate (P = .04). In the substudy, the diagnosis time by using the EC-V pattern was shorter
than that with the EC-C pattern (P < .001).
Limitations
A single-center, retrospective study.
Conclusions
The EC-V pattern saved more time than the EC-C pattern and had a diagnostic ability
comparable to that of other optical biopsy modalities.
Abbreviations:
CI (confidence interval), CLE (confocal laser endomicroscopy), EC (endocytoscopy), EC-C (endocytoscopy classification based on glandular and cellular atypia), EC-NBI (endocytoscopy in conjunction with narrow-band imaging), EC-V (endocytoscopic vascular pattern), NBI (narrow-band imaging), NBI-ME (magnifying endoscopy with narrow-band imaging), PIT (pit pattern), SSA/P (sessile serrated adenoma/polyp), VC (Vienna classification)To read this article in full you will need to make a payment
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Article Info
Publication History
Published online: June 09, 2015
Accepted:
April 26,
2015
Received:
January 13,
2015
Footnotes
DISCLOSURE: All authors disclosed no financial relationships relevant to this article.
Identification
Copyright
© 2015 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.
