Abstract
Background: The endoscopic biopsy is a prerequisite for histopathologic diagnosis. Various types
of forceps are used to obtain tissue specimens. The aim of this study was to assess
and compare the diagnostic quality of biopsy specimens obtained with a conventional
forceps and a Multibite forceps. Methods: In a prospective, partially blinded, and randomized trial that included 250 patients
referred for diagnostic upper and/or lower endoscopy, 510 biopsy specimens obtained
with the Multibite forceps were compared with 520 specimens obtained with a conventional
forceps. An experienced, blinded pathologist evaluated the specimens for diameter,
depth of specimen, artifacts, anatomic orientation, vitality, general histologic quality,
and diagnostic quality. Statistical analysis was performed by using the Fisher exact
test. A p value of < 0.05 was regarded as significant. Results: There were no statistically significant differences between the specimens obtained
with the 2 forceps. The p values for the evaluated parameters were as follows: diameter 0.45, depth of specimen
0.56, artifacts 1.0, pathoanatomic orientation 0.40, vitality 0.45, and histologic
diagnostic quality 0.53. Conclusion: The quality of biopsy specimens obtained with the Multibite forceps is comparable
with that of specimens taken with a conventional forceps. Use of the Multibite forceps
saves time in that 4 specimens can be obtained in 1 pass in situations in which a
large number of specimens are needed or when the potential for transmission of infection
is of concern. (Gastrointest Endosc 2001;54:600-4.)
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Article info
Publication history
Accepted:
July 24,
2001
Received in revised form:
February 28,
2001
Received:
December 22,
2000
Footnotes
☆Reprint requests: Amedeo C. Fantin, MD, Division of Gastroenterology, University Hospital of Bern, Inselspital, CH-3010 Bern, Switzerland.
Identification
Copyright
© 2001 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.
