A 67-year-old man with a positive fecal occult blood test underwent colonoscopy, which
revealed an 8-mm diameter elevated lesion in the rectum. The surface was smooth and
not eroded (A). It was removed by electrosurgical snare polypectomy. Histopathologic evaluation
of the resected specimen disclosed a well-demarcated lesion in the submucosa covered
by normal mucosa. The tumor contained plump spindle cells with small nuclei (B, H&E, orig. mag. ×15). The abundant cytoplasm of these cells was filled with coarse
red granules, presumably irregular lysosomes, that stained intensely with periodic
acid-Schiff stain. The nuclei and cytoplasm stained with antibodies to S-100 protein.
A histopathologic diagnosis of granular cell tumor was made. Granular cell tumor is
found in the rectum only rarely.
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© 2001 Published by Elsevier Inc. All rights reserved.
