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Case Reports| Volume 54, ISSUE 5, P643-645, November 2001

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Regression of primary gastric diffuse large B-cell lymphoma after eradication of Helicobacter pylori

  • Mitsushige Sugimoto
    Affiliations
    Department of Gastroenterology and the Department of Pathology, Seirei Hamamatsu General Hospital, and the First Department of Medicine and Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
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  • Masayoshi Kajimura
    Affiliations
    Department of Gastroenterology and the Department of Pathology, Seirei Hamamatsu General Hospital, and the First Department of Medicine and Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
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  • Yoshihiko Sato
    Affiliations
    Department of Gastroenterology and the Department of Pathology, Seirei Hamamatsu General Hospital, and the First Department of Medicine and Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
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  • Hiroyuki Hanai
    Affiliations
    Department of Gastroenterology and the Department of Pathology, Seirei Hamamatsu General Hospital, and the First Department of Medicine and Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
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  • Eizo Kaneko
    Affiliations
    Department of Gastroenterology and the Department of Pathology, Seirei Hamamatsu General Hospital, and the First Department of Medicine and Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
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  • Hiroshi Kobayashi
    Affiliations
    Department of Gastroenterology and the Department of Pathology, Seirei Hamamatsu General Hospital, and the First Department of Medicine and Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
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      Primary gastric high-grade mucosa-associated lymphoid tissue (MALT) lymphoma is generally considered refractory to eradication therapy for Helicobacter pylori and therefore is usually treated by surgical resection or by chemotherapy with or without irradiation as for malignant lymphoma.
      • Schechter NR
      • Portlock CS
      • Yahalom J.
      Treatment of mucosa-associated lymphoid tissue lymphoma of the stomach.
      • Durr ED
      • Bonner JA
      • Strickler JG
      • Martenson JA
      • Chen MG
      • Habermann TM
      • et al.
      Management of stage I E primary gastric lymphoma.
      There are several reports of regression of primary gastric high-grade MALT lymphoma after eradication therapy of H pylori alone.
      • Boot H
      • Jong D
      • Heerde PV
      • Taal B.
      Role of Helicobacter pylori eradication in high-grade MALT lymphoma.
      • Ng W-W
      • Lam C-P
      • W KG
      • Chau W-K
      • Li AF-Y
      • Huang C-C
      • et al.
      Regression of high-grade gastric mucosa-associated lymphoid tissue lymphoma with Helicobacter pylori after triple antibiotic therapy.
      • Parsonnet J
      • Hansen S
      • Rodriguez L
      • Gelb AB
      • Warnke RA
      • Jellum E
      • et al.
      Helicobacter pylori infection and gastric lymphoma.
      This is a description of a case of gastric diffuse large B-cell lymphoma that regressed after eradication therapy for H pylori, and a discussion of the potential use of this form of treatment.
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      References

        • Schechter NR
        • Portlock CS
        • Yahalom J.
        Treatment of mucosa-associated lymphoid tissue lymphoma of the stomach.
        J Clin Oncol. 1998; 16: 1916-1921
        • Durr ED
        • Bonner JA
        • Strickler JG
        • Martenson JA
        • Chen MG
        • Habermann TM
        • et al.
        Management of stage I E primary gastric lymphoma.
        Acta Haematol. 1995; 94: 59-68
        • Boot H
        • Jong D
        • Heerde PV
        • Taal B.
        Role of Helicobacter pylori eradication in high-grade MALT lymphoma.
        Lancet. 1995; 346: 448-449
        • Ng W-W
        • Lam C-P
        • W KG
        • Chau W-K
        • Li AF-Y
        • Huang C-C
        • et al.
        Regression of high-grade gastric mucosa-associated lymphoid tissue lymphoma with Helicobacter pylori after triple antibiotic therapy.
        Gastrointest Endosc. 2000; 51: 93-96
        • Parsonnet J
        • Hansen S
        • Rodriguez L
        • Gelb AB
        • Warnke RA
        • Jellum E
        • et al.
        Helicobacter pylori infection and gastric lymphoma.
        N Engl J Med. 1994; 330: 1267-1271
        • Wotherspoon AC
        • Doglioni C
        • Diss TC
        • Pan L
        • Moschini A
        • Boni M
        • et al.
        Regression of primary low grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori.
        Lancet. 1993; 342: 575-577
        • Roggero E
        • Zucca E
        • Pinotti G
        • Pascarella A
        • Capella C
        • Savio A
        • et al.
        Eradication of Helicobacter pylori infection in primary gastric lymphoma of mucosa-associated lymphoid tissue.
        Ann Intern Med. 1995; 122: 767-769
        • Montalban C
        • Manzanal A
        • Boixeda D
        • Redondo C
        • Alvarez I
        • Calleja JL
        • et al.
        Helicobacter pylori eradication for the treatment of low-grade gastric MALT lymphoma: follow-up together with sequential molecular studies.
        Ann Oncol. 1997; 8: 37-39
        • Sackmann M
        • Morgner A
        • Rudolph B
        • Neubauer A
        • Thiede C
        • Schulz H
        • MALT Lymphoma Study Group
        • et al.
        Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging.
        Gastroenterology. 1997; 113: 1087-1090
        • Chan JK
        • Ng CS
        • Isaacson PG.
        Relationship between high-grade lymphoma and low-grade B-cell mucosa-associated lymphoid tissue lymphoma (MALToma) of the stomach.
        Am J Pathol. 1990; 136: 1153-1164
        • Seymour JF
        • Anderson RP
        • Bhathal PS.
        Regression of gastric lymphoma with therapy for Helicobacter pylori infection.
        Ann Int Med. 1997; 127 ([letter]): 247
        • Bayerdorffer E
        • Neubauer A
        • Rudolph B
        • Thiede C
        • Lehn N
        • Eidt S
        • et al.
        Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection.
        Lancet. 1995; 345: 1591-1594
        • Takahara Y
        • Haruma K
        • Tsuda T
        • Sumii K
        • Kajiyama G.
        Apparent spontaneous regression of primary malignant lymphoma of the stomach.
        Endoscopy. 1992; 24: 735-736
        • Takenaka R
        • Tomoda J
        • Sakataa T
        • Ichiba T
        • Motoi M
        • Mizuno M
        • et al.
        Mucosa-associated lymphoid tissue lymphoma of the rectum that regressed spontaneously.
        J Gastroenterol Hepatol. 2000; 15: 331-335
        • Savarrio L
        • Gibson J
        • Dunlop DJ
        • O'Rourke N
        • Fitzsimons EJ.
        Spontaneous regression of an anaplastic large cell lymphoma in the oral cavity: first reported case and review of the literature.
        Oral Oncol. 1999; 35: 609-613
        • Nagashima R
        • Takeda H
        • Maeda K
        • Ohno S
        • Takahashi T.
        Regression of duodenal mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori.
        Gastroenterol. 1996; 111: 1674-1678
        • Raderer M
        • Pfeffel F
        • Pohl G
        • Mannhalter C
        • Valencak J
        • Chott A.
        Regression of colonic low grade B cell lymphoma of the mucosa associated lymphoid tissue type after eradication therapy.
        Gut. 2000; 46: 133-135
        • Alken S
        • Karcher DS
        • Newman MA
        • Cohen P.
        Regression of salivary gland MALT lymphoma after treatment for Helicobacter pylori.
        Lancet. 1996; 348: 268-269
        • Ben-Ayed F
        • Halphen M
        • Najjar T
        • Boussene H
        • Jaafoura H
        • Bouguerra A
        • et al.
        Treatment of alpha chain disease. Results of prospective study in 21 Tunisian patients by the Tunisian-French International Study Group.
        Cancer. 1989; 63: 1251-1256
        • Morgner A
        • Lehn N
        • Anderson LP
        • Thiede C
        • Bennedsen M
        • Trebesius K
        • et al.
        Helicobacter heilmannii-associated primary gastric low grade MALT lymphoma: complete remission after curing the infection.
        Gastroenterol. 2000; 118: 821-828