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Background: Advances in optical and computer technology have enabled the development of a device
that uses white-light reflectance spectrophotometry to measure capillary hemoglobin
saturation in intestinal mucosa during colonoscopy.
Methods: Studies were performed with the colon oximeter in anesthetized animals and patients
undergoing colonoscopy.
Results: Mean (SD) mucosal hemoglobin saturation in the normal colon was 72% (3.5%). In an
animal model, ischemia induced by arterial ligation and hypoxemia via hypoxic ventilation
each resulted in a decrease of over 40% in the mucosal saturation. In patients with
colon polyps, ischemia induced by epinephrine injection, stalk ligation with a loop,
or clipping of the polyp stalk each resulted in a decrease of over 40% in the mucosal
saturation (p<0.02). In contrast, saline solution injection did not decrease the mucosal saturation.
Conclusions: A novel device for measuring capillary hemoglobin saturation in intestinal mucosa
during colonoscopy is capable of providing reproducible measurements in normal patients
and clearly detects dramatic decreases in saturation with ischemic and hypoxic insults.
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Article info
Publication history
Accepted:
December 20,
2002
Received in revised form:
October 23,
2002
Received:
August 1,
2002
Identification
Copyright
© 2003 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc.
