Colorectal cancer (CRC) is the fourth most commonly diagnosed cancer and the second
leading cause of cancer-related deaths in the United States.2 Each year, approximately
140,000 individuals are diagnosed with CRC and more than 50,000 will die from this
malignancy.
2
The 5-year survival rate for early-stage cancers is greater than 90%, whereas the
5-year survival rate for those diagnosed with widespread cancer is less than 10%.
3
There is indirect evidence that most cancers develop from adenomatous polyps and
that on average it takes 10 years for a <1 cm polyp to transform into invasive CRC.
4
,
5
Given the finding that adenomatous polyps are precursors to cancer and that polyps
and early cancers are usually asymptomatic, there is a strong rationale to support
screening asymptomatic individuals for early cancer detection and prevention.To read this article in full you will need to make a payment
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© 2006 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.
