Abbreviations:AF (atrial fibrillation), aPTT (activated partial thromboplastin time), ARISTOTLE (apixaban for reduction in stroke and thromboembolic events in atrial fibrillation), ASGE (American Society for Gastrointestinal Endoscopy), INR (international normalized ratio), NOAC (novel oral anticoagulant), NSAID (nonsteroidal anti-inflammatory drug), PCC (prothrombin complex concentrate), PPI (proton pump inhibitor), PT (prothrombin time), RE-LY (randomized evaluation of long term anticoagulant therapy), ROCKET-AF (rivaroxaban once daily oral direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation), RR (relative risk)
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DISCLOSURES: J. Desai was supported by a grant from the Digestive Disease Research Foundation. C. Granger received grants from Bristol-Myers Squibb, Pﬁzer, AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, the Medtronic Foundation, Merck, Sanoﬁ-Aventis, Astellas, and the Medicines Company. He received consulting fees from AstraZeneca, Boehringer Ingelhelm, Bristol-Myers Squibb, GlaxoSmithKline, Hoffmann-LaRoche, Novartis, Otsuka Pharmaceutical, Sanoﬁ-Aventis, Lilly, Pﬁzer, and the Medicines Company and travel grants from Hoffmann-La Roche, Novartis, and Pﬁzer. J. Weitz is a consultant for and received honoraria from BMS, Pfizer, Boehringer Ingelhelm, Bayer, Janssen Pharmaceuticals, Daiichi Sankyo, Merck, and Takeda. J. Aisenberg is a consultant for and received honoraria from Boehringer Ingelhelm. No other financial relationships relevant to this publication were disclosed.
See CME section; p. 342.