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A randomized, controlled trial comparing real-time insertion pain during colonoscopy confirmed water exchange to be superior to water immersion in enhancing patient comfort

Published:September 25, 2014DOI:https://doi.org/10.1016/j.gie.2014.07.029

      Background

      A recent American Society for Gastrointestinal Endoscopy Technology Status Evaluation Report recommended comparative studies of water-aided colonoscopy methods to refine the optimal insertion technique.

      Objective

      Air insufflation (AI), water immersion (WI), and water exchange (WE) were compared head-to-head to test the hypothesis that WE produces the least insertion pain.

      Design

      Patient-blinded, prospective, randomized, controlled trials.

      Setting

      Two community hospitals in Italy.

      Patients

      First-time diagnostic or screening colonoscopy in unsedated patients with the option of on-demand sedation.

      Intervention

      Colonoscopy with AI, WI, or WE.

      Main Outcome Measurements

      Real-time maximum insertion pain (0 = none, 10 = worst). To avoid interventional bias, the timing of recording was at the discretion of the nurse assistant. Adjunct measures were implemented to ensure patient perception of minimal discomfort. Recalled pain and patients’ guess of insertion methods were recorded after colonoscopy.

      Results

      Results were merged for 576 randomized patients. Correct patient guesses lower than 33% confirmed adequate blinding. Significant correlation (Pearson coefficient 0.6, P < .0005) between real-time and recalled pain provided internal validation of the former as the primary outcome. Real-time pain (95% confidence interval [CI]: AI, 4.1 [3.7-4.5]; WI, 3.5 [3.0-3.9]; and WE, 2.5 [2.2-2.9] [P < .0005] was the lowest in the WE group. The proportions of patients completing unsedated colonoscopy based on the assigned methods were significantly different (WE, 74.7% vs WI, 62.4%; P = .009; vs AI, 65.3%; P = .04). WE required the least implementation of adjunct maneuvers.

      Limitations

      Unblinded colonoscopists.

      Conclusion

      The current findings with an internally validated primary outcome in adequately blinded patients support the hypothesis that WE is superior to WI in attenuating real-time insertion pain and enhancing completion of unsedated colonoscopy.

      Abbreviations:

      AI (air insufflation), ANOVA (analysis of variance), CI (confidence interval), RCT (randomized controlled trial), SD (standard deviation), VAS (visual analogue scale), WE (water exchange), WI (water immersion)
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      Linked Article

      • Erratum
        Gastrointestinal EndoscopyVol. 81Issue 5
        • Preview
          In the article “A randomized, controlled trial comparing real-time insertion pain during colonoscopy confirmed water exchange to be superior to water immersion in enhancing patient comfort” (Gastrointest Endosc 2015;81:557-66), there was an error in Figure 1. The corrected figure appears below:
        • Full-Text
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      • Discrepancy in the classification of water immersion from water exchange colonoscopy
        Gastrointestinal EndoscopyVol. 83Issue 3
        • Preview
          We read with interest the article by Cadoni et al.1 Water exchange (WE) colonoscopy seems superior to water immersion (WI); however, there is a lack of consensus on the clear distinction between these 2 procedures.2,3
        • Full-Text
        • PDF