Original article Clinical endoscopy| Volume 84, ISSUE 6, P893-899, December 2016

Long-term outcomes of endoscopic multiband mucosectomy for early esophageal squamous cell neoplasia: a retrospective, single-center study

Published:April 20, 2016DOI:

      Background and Aims

      Endoscopic multiband mucosectomy (EMBM) has been used to treat early Barrett’s esophagus and esophagogastric junction neoplasia, yet it is seldom reported for the treatment of early esophageal squamous cell neoplasia. Here we retrospectively evaluated the feasibility, safety, and efficacy of EMBM for early esophageal squamous cell neoplasia.


      A total of 125 patients were included in the study. Lesions were delineated using electrocoagulation and resected using the EMBM technique. The primary outcomes were local recurrence and adverse events. Secondary outcomes were histology of the endoscopic resection specimens, specimen area, and speed of resection. All patients were followed up endoscopically.


      There were 135 esophageal lesions, of which 40 were pathologically diagnosed as low-grade intraepithelial neoplasia, 57 as high-grade intraepithelial neoplasia, 34 as early esophageal cancer, and 4 as squamous epithelium without neoplasia. No severe adverse events were observed, except for 1 perforation, which was treated by application of clips. The median follow-up was 27.75 months. Three patients had local recurrence and were endoscopically treated again. Local recurrence rate was 2.4% (3/125). No deaths occurred during the follow-up. All specimens were visible with a dividing rule, and the mean specimen area was 4.63 cm2. Mean operation time was 31.2 ± 17.4 minutes. Mean speed of resection was 6.74 min/cm2.


      EMBM seems to be effective and safe for patients with early esophageal squamous cell neoplasia. The long-term recurrence rate is low.


      APC (argon plasma coagulation), EMBM (endoscopic multiband mucosectomy), ESCC (esophageal squamous cell cancer), ESCN (esophageal squamous cell neoplasia), ESD (endoscopic submucosal dissection), HGIN (high-grade intraepithelial neoplasia), IQR (interquartile range), LGIN (low-grade intraepithelial neoplasia)
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