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When used for tissue ablation, ethanol induces rapid cell death by means of cell lysis,
protein denaturation, and vascular occlusion. Having the benefit of being widely available
and cost effective, ethanol is broadly used, with a historical use in interventional
gastroenterology for celiac plexus neurolysis. Recently, there has been interest in
incorporating alcohol ablation into part of the management algorithm for pancreatic
cysts. Isolated case reports describe the application of this technique for the treatment
of a variety of solid malignant lesions. However, the scarcity of current published
information limits the wider use of this intervention. Here, we describe a series
of patients for whom endoscopic alcohol ablation of solid tumors was used as part
of a multidisciplinary approach in patients with otherwise difficult-to-treat solid
neoplasms. Particular interest is given to describing the technique, measures of therapeutic
benefit, and safety profile of this developing skill (Fig. 1; Video 1, available online at www.giejournal.org).
Figure 1Endoscopic alcohol ablation of peripheral nerve sheath tumor.
