When used for tissue ablation, ethanol induces rapid cell death by means of cell lysis, protein denaturation, and vascular occlusion. Having the benefit of being widely available and cost effective, ethanol is broadly used, with a historical use in interventional gastroenterology for celiac plexus neurolysis. Recently, there has been interest in incorporating alcohol ablation into part of the management algorithm for pancreatic cysts. Isolated case reports describe the application of this technique for the treatment of a variety of solid malignant lesions. However, the scarcity of current published information limits the wider use of this intervention. Here, we describe a series of patients for whom endoscopic alcohol ablation of solid tumors was used as part of a multidisciplinary approach in patients with otherwise difficult-to-treat solid neoplasms. Particular interest is given to describing the technique, measures of therapeutic benefit, and safety profile of this developing skill (Fig. 1; Video 1, available online at www.giejournal.org).
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Published online: July 13, 2016Todd H. Baron, MD, G. S. Raju, MD, Editors for VideoGIE
Copyright © 2016 by the American Society for Gastrointestinal Endoscopy