Background and Aims
Linked color imaging (LCI), a recently developed technology, uses a laser endoscopic
system to enhance the color separation of red color to depict red and white colors
more vividly. The benefits of LCI in the detection of colorectal polyps remain unknown.
The aim of this study was to assess the ability of LCI to improve the detection of
colorectal polyps compared with white-light (WL) endoscopy.
Methods
We performed a multicenter, crossover, prospective, randomized controlled trial in
3 hospitals in China. All patients underwent crossover colonoscopies with LCI and
WL endoscopy in a randomized order. All lesions were removed during the second endoscopic
procedure. The primary outcome measure was the difference in sensitivity between LCI
and WL endoscopy for the detection of colorectal polyps. The secondary outcome measures
were the adenoma detection rate per patient in the 2 groups and the factors associated
with polyp miss rates.
Results
A total of 152 patients were randomized, and 141 were included in the analysis. The
overall polyp detection rate increased significantly by 24% for LCI colonoscopy, corresponding
to a higher sensitivity with LCI than with WL endoscopy (91% vs 73%, P < .0001). Furthermore, LCI identified significantly more patients (32%) with polyps.
The per-patient adenoma detection rate was significantly higher for LCI than for WL
endoscopy (37% vs 28%; 95% confidence interval, 2.39%-19.41%).
Conclusions
LCI improves the detection of colorectal polyps and adenomas during colonoscopy. (Clinical
trial registration number: NCT02724397.)
Abbreviations:
BBPS (Boston Bowel Preparation Scale), BLI (blue laser image), CRC (colorectal cancer), IEE (image-enhanced endoscopic), LCI (linked color imaging), NBI (narrow-band imaging), WL (white light)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: March 09, 2017
Accepted:
February 23,
2017
Received:
December 2,
2016
Footnotes
DISCLOSURE: All authors disclosed no financial relationships relevant to this publication.
See CME section; p. 731.
If you would like to chat with an author of this article, you may contact Professor Liu at [email protected] or Professor Nong at [email protected]
Identification
Copyright
© 2017 by the American Society for Gastrointestinal Endoscopy
