The vast majority of patients with pancreatic ductal adenocarcinoma (PDA) are not
candidates for curative resection. Overall survival rates in this group of patients
remain exceptionally low. Pancreatic cancer organoids are tumor models of individualized
human PDA that can be rapidly generated from surgically resected tumors. Organoids
simulate the full spectrum of a patient’s tumor, including stromal elements believed
to be responsible for chemotherapy resistance. Hence, they can be used for testing
personalized treatment strategies. For surgically unresectable patients, creation
of human PDA organoids at the time of tissue diagnosis could allow this group of patients
to benefit from precision medicine with personalized treatment.
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© 2017 Published by Elsevier Inc.
