Background and Aims
Fistulas in patients with inflammatory bowel disease (IBD) pose a key challenge in
the management of these patients. We aimed to describe a novel endoscopic method to
treat patients with IBD who have fistulas.
Methods
A cohort of 29 consecutive patients with fistulas and IBD were identified in the registry
of our interventional IBD unit. An endoscopic fistulotomy with needle-knife was performed.
The primary outcome was healing of the fistula without the need for surgical intervention.
Results
A total of 29 patients underwent endoscopic fistulotomy; and the mean (± standard
deviation) age of patients undergoing the procedure was 44.2 ± 14.6 years. Thirteen
patients were male (44.8%), and 16 were female (55.2%). Twenty-six patients (89.6%)
achieved complete resolution of the fistula as confirmed by endoscopy with a guidewire
and/or cross-sectional abdominal imaging, with 10 patients (34.4%) requiring a single
endoscopic treatment session. Three patients (10.3%) had a persistent fistula and
required surgical intervention. One patient had postoperative bleeding requiring blood
transfusion and hospitalization.
Conclusion
Endoscopic fistulotomy with a needle-knife appears to be safe and effective in treating
IBD-related fistulas.
Graphical abstract

Graphical Abstract
Abbreviations:
CD (Crohn’s disease), IBD (inflammatory bowel disease), i-IBD (interventional IBD center), IPAA (ileal pouch anal anastomosis), OTSC (over-the scope clip), SD (standard deviation)To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Gastrointestinal EndoscopyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Ileal pouch anal anastomosis: analysis of outcome and quality of life in 3707 patients.Ann Surg. 2013; 257: 679-685
- Endoscopic therapy in Crohn’s disease: principle, preparation, and technique.Inflamm Bowel Dis. 2015; 21: 2222-2240
- Risk factors associated with ileal pouch-related fistula following restorative proctocolectomy.Br J Surg. 2005; 92: 1270-1276
- Factors associated with ileoanal pouch failure in patients developing early or late pouch-related fistula.Dis Col Rectum. 2011; 54: 446-453
- Infliximab maintenance therapy for fistulizing Crohn’s disease.N Engl J Med. 2004; 350: 876-885
- Endoscopic needle knife fistulotomy technique for ileal pouch-to-pouch fistula.Endoscopy. 2015; 47: E261
- Exploring endoscopic therapy for Crohn’s disease-related fistula and abscess.Gastrointest Endosc. 2017; 85: 1133-1143
- Intraoperative, postoperative and reoperative problems with ileoanal pouches.Br J Surg. 2012; 99: 454-468
- Long-term healing of Crohn’s anal fistulas with fibrin glue injection.Aliment Pharmacol Ther. 2005; 21: 1453-1457
- International multicenter experience with an over-the-scope clipping device for endoscopic management of GI defects (with video).Gastrointest Endosc. 2014; 80: 610-622
- Endoscopically placed guidewire-assisted seton for an ileal pouch-pouch fistula.Gastrointest Endosc. 2015; 82: 575-576
- Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn’s disease: a phase 3 randomised, double-blind controlled trial.Lancet. 2016; 388: 1281-1290
Article info
Publication history
Published online: February 28, 2018
Accepted:
February 20,
2018
Received:
May 29,
2017
Footnotes
DISCLOSURE: B. Shen is supported by the Ed and Joey Story Endowed Chair. All other authors disclosed no financial relationships relevant to this publication.
If you would like to chat with an author of this article, you may contact Dr Shen at [email protected]
Identification
Copyright
© 2018 by the American Society for Gastrointestinal Endoscopy