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292 CONFOCAL LASER ENDOMICROSCOPY REVEALS DIFFERENTIAL RESPONSE IN PATIENTS WITH ACTIVE ULCERATIVE COLITIS UNDERGOING ANTI-INTEGRIN COMPARED TO ANTI-TNF-ALPHA THERAPY

      Endoscopic quantification of inflammation in ulcerative colitis(UC) is limited to superficial criteria. Mucosal healing is only validated after 8 weeks of treatment and therefore cannot predict early therapy response in UC patients undergoing biological therapy with either anti-integrin or anti-TNF-alpha antibodies. Confocal Laserendomicroscopy(CLE) allows real-time visualisation of dynamic changes of the mucosal anatomy and might therefore be a reliable tool for an exact quantification of inflammation in UC.
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