A 63-year-old man presented with odynophagia and retrosternal pain. Previously, prednisolone
and cyclophosphamide were administered for severe interstitial pneumonia. The first
EGD showed diffuse maplike erosions with exfoliation of the epithelium in the distal
esophagus (A). Histologic analysis revealed multinucleated cells with ground-glass nuclei (B, arrowheads). His serum herpes simplex virus–immunoglobulin-M level was elevated to 4.49 (antibody
index). Acyclovir was administered for herpes simplex virus–induced esophagitis, and
the symptoms improved. In 9 months, he experienced recurrence of odynophagia and underwent
a second EGD.
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Publication history
Published online: April 14, 2019
Mohamed O. Othman, MD, Associate Editor for Focal PointsIdentification
Copyright
© 2019 by the American Society for Gastrointestinal Endoscopy