Endoscopists systematically undersample patients with long-segment Barrett’s esophagus: an analysis of biopsy sampling practices from a quality improvement registry

      Background and Aims

      Guidelines recommend systematic biopsy sampling in Barrett’s esophagus (BE) to reduce sampling error. Adherence to this biopsy sampling protocol has been suggested as a quality indicator; however, estimates of adherence are not available. Using a national registry, we assessed adherence and identified predictors of adherence to biopsy sampling protocols.

      Methods

      We analyzed data from the GI Quality Improvement Consortium Registry that included procedure indication, demographics, endoscopy, and pathology results. Patients with an indication of BE screening/surveillance or an endoscopic finding of BE were included. Adherence to the Seattle protocol was assessed by dividing BE length by number of pathology jars, with a ratio ≤2.0 with rounding down (lenient definition) or rounding up (stringent definition) for odd BE lengths considered adherent. Variables associated with adherence were assessed using generalized estimating equations to control for clustering within individual physicians.

      Results

      Of 786,712 EGDs assessed, 58,709 (7.5%) EGDs in 53,541 patients met inclusion criteria (mean age, 61.3 years; 60.4% men; 90.2% white; mean BE length, 2.3 cm). When the lenient and stringent definitions for adherence were used, 87.8% and 82.7% of EGDs were adherent, respectively. Increasing BE length was the most significant predictor of nonadherence (odds ratio, .69; 95% confidence interval, .67-.71). Other predictors were increasing age, male gender, increasing American Society of Anesthesiologists class, and practice location. Performance of EGD by nongastroenterologist physicians was associated with nonadherence (odds ratio, .07; 95% confidence interval, .06-.10).

      Conclusions

      Nearly 20% of endoscopies performed in BE patients were not adherent to the Seattle protocol. As BE length increases, endoscopists become less compliant with odds of nonadherence increasing by 31% with every 1-cm increase in length.

      Abbreviations:

      ASA (American Society of Anesthesiologists), BE (Barrett’s esophagus), CI (confidence interval), EAC (esophageal adenocarcinoma), GIQuIC (GI Quality Improvement Consortium), HGD (high-grade dysplasia), LGD (low-grade dysplasia)
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      Linked Article

      • Dysplasia detection in Barrett's esophagus: Is the glass half full or half empty?
        Gastrointestinal EndoscopyVol. 90Issue 5
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          Endoscopic surveillance is currently recommended in patients with Barrett's esophagus (BE) to detect prevalent and incident dysplasia/esophageal adenocarcinoma. This strategy is underpinned by the concepts that (1) dysplasia can be treated endoscopically to prevent early gastric cancer (EAC),1 and (2) early-stage EAC (without symptomatic dysphagia and muscularis propria invasion) can be successfully treated (endoscopically) with excellent long-term survival.2
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