New concept for colonoscopy including side optics and artificial intelligence

Published:December 17, 2021DOI:

      Background and Aims

      Adenoma detection rate is the crucial parameter for colorectal cancer screening. Increasing the field of view with additional side optics has been reported to detect flat adenomas hidden behind folds. Furthermore, artificial intelligence (AI) has also recently been introduced to detect more adenomas. We therefore aimed to combine both technologies in a new prototypic colonoscopy concept.


      A 3-dimensional–printed cap including 2 microcameras was attached to a conventional endoscope. The prototype was applied in 8 gene-targeted pigs with mutations in the adenomatous polyposis coli gene. The first 4 animals were used to train an AI system based on the images generated by microcameras. Thereafter, the conceptual prototype for detecting adenomas was tested in a further series of 4 pigs.


      Using our prototype, we detected, with side optics, adenomas that might have been missed conventionally. Furthermore, the newly developed AI could detect, mark, and present adenomas visualized with side optics outside of the conventional field of view.


      Combining AI with side optics might help detect adenomas that otherwise might have been missed.

      Graphical abstract


      AI (artificial intelligence), APC (adenomatous polyposis coli)
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