Background and Aims
One-liter polyethylene glycol plus ascorbic acid (PEG-ASC) improves patient tolerability,
but some patients still show low tolerability to a relatively high content of ASC.
This study aimed to improve the tolerability and safety of 1-L PEG with low-dose ASC
in comparison with standard 1-L and 2-L PEG-ASC.
Methods
This was a randomized, controlled, double-blinded, multicenter, noninferiority trial
involving 215 healthy adults who underwent colonoscopy from June 2020 to January 2021.
Efficacy, tolerability, and safety were compared among 1-L PEG with low-dose ASC (50%
lower ASC concentration in group A and 25% lower ASC concentration in groups B and
C) and standard 1-L and 2-L PEG-ASC with all split regimens.
Results
One-liter PEG with low-dose ASC (groups A-C) had similar bowel cleansing efficacies
according to the Harefield Cleansing Scale and Boston Bowel Preparation Scale, without
negative clinical performance, compared with standard 1-L and 2-L PEG-ASC preparation
(all P > .1). One-liter PEG with low-dose ASC had better tolerability compared with 2-L
PEG-ASC and less residual fluid retention in the stomach compared with 1-L PEG-ASC,
proportional to the amount of ASC. No significant differences were found in the incidences
of overall adverse events, mild adverse events, or death or in the occurrence of gastroduodenal
erosion or ulcer in upper endoscopy.
Conclusions
One-liter PEG with low-dose ASC (25%-50% reduction in dose) for bowel cleansing showed
similar efficacy and safety compared with standard 1-L or 2-L PEG-ASC, better tolerability
compared with 2-L PEG-ASC, and less residual gastric fluid retention compared with
standard 1-L PEG-ASC. (Clinical trial registration number: KCT0005490.)
Abbreviations:
AE (adverse event), ADR (adenoma detection rate), ASC (ascorbic acid), BBPS (Boston Bowel Preparation Scale), HCS (Harefield Cleansing Scale), PDR (polyp detection rate), PEG (polyethylene glycol), PEG-ASC (polyethylene glycol plus ascorbic acid)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: March 10, 2022
Accepted:
March 3,
2022
Received:
December 12,
2021
Footnotes
DISCLOSURE: All authors disclosed no financial relationships. Research support for this study was provided by Korean Association for the Study of Intestinal Diseases (KASID), and Taejoon Pharm Co, Ltd, South Korea.
If you would like to chat with an author of this article, you may contact Dr Cha at [email protected]
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© 2022 by the American Society for Gastrointestinal Endoscopy
