Background and Aims
ORISE (Boston Scientific, Marlborough, Mass, USA) is a viscous gel used for submucosal
injection. We noted anecdotally that ORISE is associated with submucosal distortion
of EMR scars at follow-up.
Methods
We blindly reviewed photographs of 30 consecutive EMR scars at follow-up after resections
using ORISE and 30 resections using other agents. Distortion was scored on a scale
of 0 (no submucosal distortion) to 5 (overt submucosal distortion).
Results
The median submucosal distortion score at follow-up in ORISE cases was 3 (range, 0-5)
versus 0 (range, 0-2) with other fluids (P < .001, Mann-Whitney U test) by 1 reviewer and 3 (range, 0-5) versus 2 (range, 0-5),
respectively, by a second reviewer (P = .018). The kappa value for agreement in the submucosal distortion scores between
the 2 experts was .148 for all photographs and .214 for the ORISE cases (overall minimal
agreement).
Conclusions
ORISE can cause submucosal distortion in the region of EMR scars when they are viewed
at follow-up. Such distortions must not be mistaken for submucosal tumor growth.
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Article Info
Publication History
Published online: May 09, 2022
Accepted:
April 30,
2022
Received:
December 17,
2021
Footnotes
DISCLOSURE: The following authors disclosed financial relationships: J. M. DeWitt: Consultant for Boston Scientific. D. K. Rex: Consultant for Olympus Corporation, Boston Scientific, Aries Pharmaceutical, Braintree Laboratories, Lumendi, Ltd, Norgine, Endokey, GI Supply, Medtronic, and Acacia Pharmaceuticals; research support from EndoAid, Olympus Corporation, Medivators, Erbe USA Inc, and Braintree Laboratories; shareholder in Satisfai Health. All other authors disclosed no financial relationships.
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© 2022 by the American Society for Gastrointestinal Endoscopy
