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Letters to the Editor| Volume 97, ISSUE 3, P601, March 2023

Getting the full picture: let’s always include sustainability in trials reporting new technology!

      To the Editor:
      We read with interest the report by Luo et al
      • Luo X.
      • Ji M.
      • Zhang S.
      • et al.
      Disposable versus reusable gastroscopes: a prospective randomized noninferiority trial.
      of their noninferiority trial concluding that disposable gastroscopes are a viable alternative to their reusable counterparts for “routine examination, bedside first aid, and some certain circumstances.”
      Although we think that the recent increase in interest in the efficiency of disposable endoscopes is exciting, we are concerned about the apparent lack of attention given to sustainability and the environmental implications.
      • Rodríguez de Santiago E.
      • Dinis-Ribeiro M.
      • Pohl H.
      • et al.
      Reducing the environmental footprint of gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastroenterology and Endoscopy Nurses and Associates (ESGENA) position statement.
      Single-use endoscopes challenge the principle of reusing—1 of the 3 pillars of environmental sustainability (reduce, reuse, recycle)—and have given rise to constructive debate. Demonstrating performance similar to that of reusable endoscopes is definitely an achievement, but focusing on “technical” outcomes cannot answer the bigger question posed when we consider the paradigm shift of proposing single-use endoscopes for routine procedures. Available data are concerning and suggest that a transition to single-use duodenoscopes alone would increase CO2 emissions 20 times
      • Hernandez L.V.
      • Thu Le N.N.
      • Patnode C.
      • et al.
      Comparing the impact of reusable and single-use duodenoscopes using life cycle assessment [abstract].
      and the net waste mass by 40%.
      • Namburar S.
      • von Renteln D.
      • Damianos J.
      • et al.
      Estimating the environmental impact of disposable endoscopic equipment and endoscopes.
      There is a clear distinction between endoscope contamination and clinically relevant infection, given that most endoscope contaminations do not translate into clinical implications for patients. Human error seems to be the most common cause behind inadequate endoscope reprocessing and can be addressed by training programs and standardized education.
      • Beilenhoff U.
      • Biering H.
      • Blum R.
      • et al.
      Prevention of multidrug-resistant infections from contaminated duodenoscopes: position statement of the European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastroenterology Nurses and Associates (ESGENA).
      Whereas patient safety is paramount, the principle of achieving an “as low as reasonably practicable” infection risk is now considered by several scientific societies and healthcare institutions to balance clinical, societal, financial, and environmental costs.
      • Shoup T.
      As low as reasonably practicable: an approach to managing device risk.
      To advance the discussion of this topic, studies of novel single-use endoscopes should disclose more about the materials used for production, life-cycle assessment, and plans for recycling components. Only by considering these factors in their trial design can future noninferiority trials account for all aspects of this difficult and societally relevant issue.

      Disclosure

      All authors disclosed no financial relationships.

      References

        • Luo X.
        • Ji M.
        • Zhang S.
        • et al.
        Disposable versus reusable gastroscopes: a prospective randomized noninferiority trial.
        Gastrointest Endosc. 2022; 96: 250-261
        • Rodríguez de Santiago E.
        • Dinis-Ribeiro M.
        • Pohl H.
        • et al.
        Reducing the environmental footprint of gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastroenterology and Endoscopy Nurses and Associates (ESGENA) position statement.
        Endoscopy. 2022; 54: 797-826
        • Hernandez L.V.
        • Thu Le N.N.
        • Patnode C.
        • et al.
        Comparing the impact of reusable and single-use duodenoscopes using life cycle assessment [abstract].
        Gastrointest Endosc. 2021; 93 (Hernandez LV, Thu Le NN, Patnode C, et al. ID: 3526786): AB29
        • Namburar S.
        • von Renteln D.
        • Damianos J.
        • et al.
        Estimating the environmental impact of disposable endoscopic equipment and endoscopes.
        Gut. 2022; 71: 1326-1331
        • Beilenhoff U.
        • Biering H.
        • Blum R.
        • et al.
        Prevention of multidrug-resistant infections from contaminated duodenoscopes: position statement of the European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastroenterology Nurses and Associates (ESGENA).
        Endoscopy. 2017; 49: 1098-1106
        • Shoup T.
        As low as reasonably practicable: an approach to managing device risk.
        Biomed Instrum Technol. 2018; 52: 248