Advertisement

Endoscopic radiofrequency ablation for ingrowth occlusion following bilateral metal stenting for malignant hilar biliary obstruction: A prospective pilot study

Published:October 08, 2022DOI:https://doi.org/10.1016/j.gie.2022.09.025
      This paper is only available as a PDF. To read, Please Download here.

      ABSTRACT

      Background

      Endoscopic biliary radiofrequency ablation (RFA) may be an option for the treatment of ingrowth occlusion after self-expandable metal stent (SEMS) deployment; however, its utility remains uncertain. This study aimed to examine the feasibility of RFA for the palliation of ingrowth after bilateral SEMS placement in patients with malignant hilar biliary obstruction.

      Methods

      This prospective, single-center, pilot study enrolled 30 patients who met the eligibility criteria between April 2020 and March 2022. The study outcomes included technical success, clinical success, recurrent biliary obstruction (RBO), and adverse events (AE) besides RBO associated with RFA for ingrowth occlusion. Furthermore, the factors predictive of clinical success were evaluated.

      Results

      The technical and clinical success rates were 93.3% (28/30) and 71.4% (20/28), respectively. The rates of early and late AEs were 6.7% (2/30) and 10.0% (2/20), respectively. The incidence rate of RBO after RFA was 45.0% (9/20), and the median time to RBO was 163 days. Multivariate analysis of the factors affecting clinical success revealed a positive association between the recanalization diameter on the ingrown part within the SEMS (odds ratio, 1.13; 95% confidence interval, 1.01-1.26; P=0.038). The calculated optimal cutoff for the ratio of the recanalization diameter to the SEMS diameter for predicting clinical success was 51.1%.

      Conclusions

      Endoscopic biliary RFA elicited promising results, with good long-term stent patency and without the requirement of any additional stent placement, for the palliation of ingrowth occlusion after bilateral SEMS placement. However, the clinical success rate was insufficient, necessitating improvements in the future.

      Keywords

      Acronyms: SEMS (self-expandable metal stent), SBS (stent-by-stent), SIS (stent-in-stent), MHBO (malignant hilar biliary obstruction), PS (plastic stent), RBO (recurrent biliary obstruction), RI (re-intervention), RFA (radiofrequency ablation), AE (adverse event)
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Gastrointestinal Endoscopy
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect