Abbreviations:POEM (Per Oral Endoscopic Myotomy), GERD (Gastroesophageal reflux disease), U.S (United States), ES (Eckardt score), GERD-HRQL (GERD-Health-related quality of life), RSI (Reflux symptom index), HM (Heller myotomy), POEM-F (Per oral endoscopic myotomy with fundoplication), NOTES (Natural orifice transluminal endoscopic surgery), BMI (Body mass index), GEJ (Gastroesophageal junction), TTSC (Through-the-scope clip), FLIP (Functional luminal imaging probe), PPI (Proton pump inhibitors), AE (Adverse event), SD (Standard deviation), DI (Distensibility index)
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•Mouen A. Khashab is a consultant for Boston Scientific, Olympus America, Medtronic, Apollo Endosurgery, Pentax and GI Supply, and receives royalties from UpToDate and Elsevier
Acknowledgements: All schematic figures were created with BioRender.com
•Apurva Shrigiriwar: Analysis and interpretation of the data and drafting of the manuscript.
•Linda Y. Zhang: Analysis and interpretation of the data and drafting of the manuscript.
•Bachir Ghandour: Drafting of the manuscript.
•Michael Bejjani: Drafting of the manuscript.
•Shruti Mony: Drafting of the manuscript.
•Amol Bapaye: Critical revision of the article for important intellectual content.
•Mouen A. Khashab: Conception, design, and final approval of the manuscript.