Advertisement

Establishment of Modified Kyoto Classification Scoring Model and its Significance in the Diagnosis of Helicobacter pylori Current Infection

  • Kaijie Wang
    Affiliations
    Department of gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China
    Search for articles by this author
  • Jing Zhao
    Affiliations
    Department of gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China
    Search for articles by this author
  • Haifeng Jin
    Affiliations
    Department of gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China

    Key Laboratory of Digestive Pathophysiology of Zhejiang Province, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
    Search for articles by this author
  • Lina Meng
    Affiliations
    Department of gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China

    Key Laboratory of Digestive Pathophysiology of Zhejiang Province, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
    Search for articles by this author
  • Yihong Fan
    Affiliations
    Department of gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China
    Search for articles by this author
  • Yanlin Zhou
    Affiliations
    Department of gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China

    Key Laboratory of Digestive Pathophysiology of Zhejiang Province, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
    Search for articles by this author
  • Cheng Ye
    Affiliations
    Department of gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China
    Search for articles by this author
  • Meng Li
    Affiliations
    Department of gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China

    Key Laboratory of Digestive Pathophysiology of Zhejiang Province, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
    Search for articles by this author
  • Panpan Ma
    Affiliations
    Department of gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China
    Search for articles by this author
  • Linwensi Zhu
    Affiliations
    Department of gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China
    Search for articles by this author
  • Yanting Ye
    Affiliations
    Department of gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China
    Search for articles by this author
  • Bin Lyu
    Correspondence
    Corresponding author: Bin Lyu, , TEL: 0086-13906515409
    Affiliations
    Department of gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China

    Key Laboratory of Digestive Pathophysiology of Zhejiang Province, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
    Search for articles by this author
Open AccessPublished:November 17, 2022DOI:https://doi.org/10.1016/j.gie.2022.11.008
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Background and Aims

      To establish a modified model of the Kyoto classification score and verify its accuracy for predicting Helicobacter pylori (Hp) infection during endoscopy.

      Methods

      Patients who underwent gastroscopy from June 2020 to March 2021 were included in this study. Atrophy, intestinal metaplasia, hypertrophy of gastric fold, nodularity, diffuse redness, sticky mucus, spotty redness, xanthoma, map-like redness, fundic gland polyp, and regular arrangement of collecting venules (RAC) were recorded according to the Kyoto classification of gastritis. The Hp infection status of the participants was determined by 13C breath test, anti-Hp antibody, and histopathological hematoxylin-eosin staining. The modified Kyoto classification scoring model was established based on univariate analysis and logistic regression analysis. The modified scoring model was used to judge the status of Hp infection in patients undergoing gastroscopy from July to September 2021 and evaluate the accuracy of the prediction.

      Results

      A total of 667 participants comprised the derivation data set, including 326 cases of Hp infection and 341 cases of Hp non-infection. Atrophy, hypertrophy of gastric fold, nodularity, diffuse redness, sticky mucus, and spotty redness were associated with Hp current infection. Thus, a new scoring model termed the modified Kyoto classification scoring model was constructed, which included atrophy, hypertrophy of gastric fold, nodularity, diffuse redness, sticky mucus, spotty redness, fundic gland polyp, and RAC as indicators. A total of 808 subjects, including 251 Hp-positive patients, comprised the validation data set to test the model.

      Conclusions

      The modified Kyoto classification scoring model improves the accuracy of endoscopic determination of Hp current infection and has clinical application potential in Chinese population.

      Keywords

      Acronyms and abbreviations:

      Hp (Helicobacter pylori), RAC (Regular arrangement of collecting venules), AUC (Area under the curve), NPV (Negative predictive value), PPV (Positive predictive values), ROC (Receiver operating characteristic curve), OR (odds ratio)