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Endoscopic intralesional steroid injections in the management of refractory esophageal strictures

      Esophageal strictures are caused by bands of submucosal fibrous tissue that encroach upon the lumen and subsequently impede the passage of ingested material from the mouth to the stomach. In children, esophageal strictures are commonly a result of peptic esophagitis,
      • Williamson RCN
      The management of peptic esophageal stricture.
      ingestion of caustics,
      • Ray III, JF
      • Myers WO
      • Lawton BR
      • Lee FY
      • Wenzel FJ
      • Sautter RD
      The natural history of liquid lye ingestion: rationale for aggressive surgical approach.
      or injury at the site of a surgical anastomosis.
      • Gryboski J
      • Walker AW
      Gastrointestinal problems in the infant (the esophagus).
      Current standards of therapy consist of esophageal dilation
      • Lindor KD
      • Ott BJ
      • Hughes Jr, RW
      Balloon dilation of upper digestive tract strictures.
      and, in refractory cases, esophageal resection at the level of stricture.
      • Mercer CD
      • Hill LD
      Surgical management of peptic esophageal stricture: twenty-year experience.
      Successful treatment of refractory strictures using intralesional steroid injections has been reported in a limited number of patients.
      • Holder TM
      • Ashcraft KW
      • Leape L
      The treatment of patients with esophageal strictures by local steroid injections.
      • Gandhi RP
      • Cooper A
      • Barlow BA
      Successful treatment of esophageal strictures without resection or replacement.
      • Kirsch M
      • Blue M
      • Desai RK
      • Sivak Jr, MV
      Intralesional steroid injections for peptic esophageal strictures.
      • Mendelsohn HJ
      • Maloney WH
      The treatment of benign strictures of the esophagus with cortisone injection.
      • Berenson GA
      • Wyllie R
      • Caulfield M
      • Steffen R
      Intralesional steroids in the treatment of refractory esophageal strictures.
      We present our experience using endoscopic intralesional steroid injections in seven patients with refractory esophageal strictures.
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